Title of article :
Discovery of active site of vinblastine as application of nanotechnology in medicine
Author/Authors :
Varmaghani، Zahra نويسنده Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran , , Monajjemi، Majid نويسنده Department of Chemistry, Science and Research Campus, Tehran, Iran , , Mollaamin، Fatemeh نويسنده Department of Chemistry, Science and Research Campus, Tehran, Iran ,
Issue Information :
دوفصلنامه با شماره پیاپی 3 سال 2014
Pages :
9
From page :
162
To page :
170
Abstract :
Objective(s): Vinblastine is antimitotic, anticancer medicine that disturbs normal microtubule formation and favours depolymerisation. Structural study and finding the active site of vinblastine are the targets of this research. Materials and Methods: Vinblastine was optimized in vacuum and then in different solvents by Density Functional Theory (DFT) method. Nuclear Magnetic Resonance (NMR) shift measurements were made in different solvents by various dielectric constants by Continuous Set of Gauge Transformations (CSGT). Results: The best structure and function of vinblastine was established. The conformational preferences may be attributed to stereoelectronic effects. The results showed that the structure of vinblastine is more stabile in water rather than the other media. The most active atoms of vinblastine were realized by various spectra of vinblastine in different media including vacuum and diverse solvents. Conclusion: Discovery of active site of vinblastine that could bind to tubulin to perform the antimitosis and anticancer effect in process of cell division was accomplished in this investigation. These data can be applicable to study the binding site of vinblastine-tubulin complex.
Keywords :
Vinblastine , Nanosystem , Density functional theory , Anticancer
Journal title :
Nanomedicine Journal
Serial Year :
2014
Journal title :
Nanomedicine Journal
Record number :
1371000
Link To Document :
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