Title of article
The synthesis, structural characterization and in vitro anti-cancer activity of novel N-{6-(ferrocenyl) ethynyl-2-naphthoyl} amino acid and dipeptide ethyl esters
Author/Authors
Andy G. Harry، نويسنده , , James Murphy، نويسنده , , William E. Butler، نويسنده , , Rachel Tiedt، نويسنده , , ?ine Mooney، نويسنده , , Jennifer C. Manton، نويسنده , , Mary T. Pryce، نويسنده , , Norma OʹDonovan، نويسنده , , Naomi Walsh، نويسنده , , John Crown، نويسنده , , Dilip K. Rai، نويسنده , , Peter T.M. Kenny، نويسنده ,
Issue Information
دوفصلنامه با شماره پیاپی سال 2013
Pages
7
From page
86
To page
92
Abstract
N-{6-(Ferrocenyl) ethynyl-2-naphthoyl} amino acid and dipeptide ethyl esters 2–8 were prepared by coupling 6-(ferrocenyl) ethynyl-2-naphthoic acid 1 to the amino acid ethyl ester GABA(OEt) and the dipeptide ethyl esters GlyGly(OEt), GlyAla(OEt), SarGly(OEt), SarAla(OEt), ProGly(OEt) and ProAla(OEt) using the standard N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC), 1-hydroxybenzotriazole (HOBt) protocol. All the compounds were fully characterized using a combination of 1H NMR, 13C NMR, DEPT-135 and 1H–13C COSY (HMQC) spectroscopy, electrospray ionization mass spectrometry (ESI-MS) and cyclic voltammetry (CV). Compounds, 2–8 showed micromolar activity in the H1299 NSCLC cell line, with IC50 values in the range of 3.2–7.2 μM.
Keywords
Ferrocene , Bioorganometallic chemistry , Cytotoxicity , Dipeptides , Lung cancer
Journal title
Journal of Organometallic Chemistry
Serial Year
2013
Journal title
Journal of Organometallic Chemistry
Record number
1371625
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