Title of article :
(2-Halogeno-5-pyridyl)dimethyl(oxiran-2-ylmethyl)silanes: New potential building blocks for the synthesis of silicon-containing drugs
Author/Authors :
Dennis Troegel، نويسنده , , FRANK MOLLER، نويسنده , , Reinhold Tacke، نويسنده ,
Issue Information :
دوفصلنامه با شماره پیاپی سال 2010
Abstract :
(2-Fluoro-5-pyridyl)dimethyl(oxiran-2-ylmethyl)silane (1a) and (2-chloro-5-pyridyl)dimethyl(oxiran-2-ylmethyl)silane (1b) were prepared in two-step syntheses, starting from allylchlorodimethylsilane. Compounds 1a and 1b were characterized by elemental analyses and NMR studies. With the synthesis of 1a and 1b, new potential building blocks for the synthesis of silicon-containing drugs have been made accessible.
Keywords :
Organosilicon chemistry , Silane , Sila drugs , Epoxides
Journal title :
Journal of Organometallic Chemistry
Journal title :
Journal of Organometallic Chemistry