Improving methodology for the preparation of uracil derivatives from Fischer carbene complexes. Microwave activation

The effect of the microwave irradiation on the reaction of alkynyl alkoxy carbene complexes with ureas is studied. The results show that the use of microwave activation could represent an alternative to the reaction in conventional conditions for the metal carbene complex chemistry. In particular, is noteworthy that the use of large amounts of solvents could be drastically reduced or even avoided and, in any case, reaction times were dramatically shortened.