Biological aspects of new organotin(IV) compounds of 3-maleimidopropionic acid

Four new compounds of organic mono carboxylic acid, 3-maleimidopropionic acid; with Bu2Sn(IV)2+, Ph3Sn(IV)+ and Cychex3Sn(IV)+ having ligand to metal ratio 1:2 and 1:1 were prepared. The spectrophotometric techniques used for structure determination like 1H-, 13C- and 119Sn-NMR, FT IR and 119mSn Mössbauer have demonstrated that the organotin(IV) moieties establish chemical bonding with the ligand through carboxylic oxygen atom. The percent CHN analyses and MS data also corroborates the spectroscopic results. During in vitro LD50, anti-fungal, anti-bacterial and anti-yeast bioassays promising results were exhibited. In vitro anti-tumour activity assays against five human tumor cell lines, MCF-7 Breast cancer–EVSA-T Breast cancer–WiDr Colon cancer–IGROV Ovarian cancer–M226 Non small cell lung cancer and anti-inflammatory screenings furnished the significant toxicities of the title complexes. In addition the triorganotin(IV) complexes were comparatively less toxic than the diorganotin(IV) complexes.