Synthesis, structures and biological activity research of novel ferrocenyl-containing 1H-1,2,4-triazole derivatives

Novel ferrocene-containing propenones have been synthesized from acetylferrocene via a Mannich-type intermediate. Sequential condensation cyclization of these propenones with phenylhydrazine afforded highly substituted 4,5-dihydropyrazole derivatives, which structures have been characterized by spectra data and single crystal X-ray diffraction analysis. In addition, these new ferrocene-containing derivatives have been evaluated for in vitro fungicidal activities against five selected fungi.