Lactose-based molecular alloys obtained by solid state vitrification

In this paper, we report the possibility to form glassy amorphous molecular alloys α-lactose/mannitol and α-lactose/budesonide by milling together pure crystalline powders of α-lactose and mannitol on the one hand, and pure crystalline powders of α-lactose and budesonide on the other hand. It is also shown that upon milling, pure mannitol undergoes a polymorphic transformation from the stable form β towards the metastable form α, while pure budesonide undergoes a complete amorphization. The results have been established by differential scanning calorimetry and by powder X-ray diffraction.