Preparation, in vitro bioactivity and drug release property of well-ordered mesoporous 58S bioactive glass

Bioactive glasses (BG) have proved to be able to chemically bond to living bone due to the formation of an apatite-like layer on its surface. In this paper, well-ordered mesoporous 58S bioactive glass (M58S) was synthesized in aqueous solution by a two-step acid-catalyzed self-assembly process combined with hydrothermal treatment. The drug release behavior of the M58S was investigated in phosphate buffered saline (PBS) at 37.5 °C for 20 days, and the assessment of in vitro bioactivity of M58S powders was carried out in simulated body fluid (SBF) at 37.5 °C. The results showed that M58S possessed good drug release behavior due to its well-ordered mesoporous structure, and a higher ability to induce hydroxyapatite formation in SBF. Therefore, well-ordered mesoporous bioactive glasses might be used as a bioactive drug release system for preparation of bone implant materials.