Title of article :
A Simple Procedure for Preparation of N-Thiazolyl and N-Thiadiazolylcantharidinimides and Evaluation of Their Cytotoxicities against Human Hepatocellular Carcinoma Cells
Author/Authors :
Pen-Yuan، نويسنده , , Lin and Sheng-Jie، نويسنده , , Shi and Hsien-Liang، نويسنده , , Shu and Hsue-Fen، نويسنده , , Chen and Chiung-Chang، نويسنده , , Lin and Pong-Chun، نويسنده , , Liu and Leng-Fang، نويسنده , , Wang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Abstract :
We made an effort to prepare effective cantharidinimides by heating the reactants 1 and 2a–j to 200°C with toluene and triethylamine to provide 10 N-thiazolyl- and N-thiadiazolylcantharidinimides 3a–j in high yields of 48–91%. All of the synthetic compounds were tested for their capability to suppress growth of the human hepatocellular carcinoma cell lines, SK-Hep-1 and Hep 3B. The results showed that compound 3f was the most potent, and it was more cytotoxic than cantharidin.
Keywords :
N-thiadiazolylcantharidinimide , N-thiazolylcantharidinimide , human hepatocellular carcinoma cell , Cytotoxicity. , Cantharidin
Journal title :
Bioorganic Chemistry: an International Journal
Journal title :
Bioorganic Chemistry: an International Journal
