Title of article
Synthesis of a peptidocalix[4]arene library and identification of compounds with hydrolytic activity
Author/Authors
Brewster، نويسنده , , R. Elizabeth and Dalton، نويسنده , , Brian G.A. and Shuker، نويسنده , , Suzanne Beckham Shuker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
6
From page
16
To page
21
Abstract
A 120 member library of peptidocalix[4]arenes was synthesized and screened for catalysis of the hydrolysis of p-nitrophenyl acetate. His-Ser-His-calix[4]arene was found to catalyze this reaction with v0 = 3.24 × 10−8 M/s, an increase of 1520% above background and 30% above the tripeptide (His-Ser-His) alone.
Keywords
Calixarenes , Catalysis , amino acids , solid-phase synthesis , Peptides
Journal title
Bioorganic Chemistry: an International Journal
Serial Year
2005
Journal title
Bioorganic Chemistry: an International Journal
Record number
1385798
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