Title of article
Parallel synthesis of 5-cyano-6-aryl-2-thiouracil derivatives as inhibitors for hepatitis C viral NS5B RNA-dependent RNA polymerase
Author/Authors
Ding، نويسنده , , Yili and Girardet، نويسنده , , Jean-Luc and Smith، نويسنده , , Kenneth L. and Larson، نويسنده , , Gary and Prigaro، نويسنده , , Brett and Wu، نويسنده , , Jim Z. and Yao، نويسنده , , Nanhua، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
13
From page
26
To page
38
Abstract
From random screening of our compound libraries, we identified a hit compound with an IC50 of 27 μM against hepatitis C viral NS5B RNA-dependent RNA polymerase. By using a parallel synthetic strategy, a series of its derivatives were synthesized. From their anti-HCV activity screening, compounds with single digital 3.8 micromolar activity were obtained.
Keywords
NS5B , Inhibitors , 5-Cyano-6-aryl-2-thiouracil derivatives , HCV
Journal title
Bioorganic Chemistry: an International Journal
Serial Year
2006
Journal title
Bioorganic Chemistry: an International Journal
Record number
1385841
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