Title of article :
Mutations in genes causing human familial isolated hyperparathyroidism do not account for hyperparathyroidism in Keeshond dogs
Author/Authors :
Skelly، نويسنده , , Barbara J. and Franklin، نويسنده , , Robin J.M. Franklin، نويسنده ,
Issue Information :
فصلنامه با شماره پیاپی سال 2007
Pages :
3
From page :
652
To page :
654
Abstract :
The roles of the calcium sensing receptor gene (CaSR) and the multiple endocrine neoplasia gene (MEN1) were investigated in Keeshond dogs with familial hyperparathyroidism. Mutations in these genes have been shown to cause familial isolated hyperparathyroidism (FIH) in humans. Affected dogs were identified through measurement of blood calcium and parathyroid hormone levels. Parathyroid tissue and whole blood was used to clone the cDNAs and individual exonic sequences of both candidate genes. No sequence abnormalities were identified when comparing normal and affected dogs, suggesting that a mapping strategy may be the most appropriate approach for identifying the genetic basis of this valuable comparative canine disease model.
Keywords :
Canine hyperparathyroidism , candidate genes , Keeshond , Animal model
Journal title :
The Veterinary Journal
Serial Year :
2007
Journal title :
The Veterinary Journal
Record number :
1392147
Link To Document :
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