Title of article
Canine specific ELISA for coagulation factor VII
Author/Authors
Knudsen، نويسنده , , Tom and Kjelgaard-Hansen، نويسنده , , Mads and Tranholm، نويسنده , , Mikael and Wiinberg، نويسنده , , Bo and Clausen، نويسنده , , Jes T. and Hansen، نويسنده , , Jens Jacob and Nichols، نويسنده , , Timothy C. and Kjalke، نويسنده , , Marianne and Jensen، نويسنده , , Asger L. and Kristensen، نويسنده , , Annemarie T.، نويسنده ,
Issue Information
فصلنامه با شماره پیاپی سال 2011
Pages
7
From page
352
To page
358
Abstract
Canine coagulation factor VII (FVII) deficiency can be hereditary or acquired and may cause life threatening bleeding episodes if untreated. FVII procoagulant activity can be measured by FVII activity (FVII:C), but assays for measurement of canine specific FVII antigen (FVII:Ag) have not been available to date. In this study, a canine specific ELISA for measurement of FVII:Ag in plasma was developed and validated. The FVII:Ag ELISA correctly diagnosed homozygous and heterozygous hereditary FVII deficiency. Together with activity based assays, such as FVII:C, the FVII:Ag ELISA should be valuable in the diagnosis of hereditary canine FVII deficiency.
Keywords
Coagulation factor , ELISA , FVII deficiency , haemostasis , PLASMA , IMMUNOASSAYS
Journal title
The Veterinary Journal
Serial Year
2011
Journal title
The Veterinary Journal
Record number
1395548
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