Author/Authors :
Zarei، Afsoon نويسنده Infertility Research Center & IVF Center, Shiraz University of Medical Sciences, Shiraz, Iran , , Parsanezhad، Mohammad Ebrahim نويسنده , , Younesi، Masoumeh نويسنده Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. , , Alborzi، Saeed نويسنده , , Zolghadri، Jaleh نويسنده Infertility Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran , , Samsami Dehaghani، Alamtaj نويسنده Department of Obstetrics and Gynecology, Shiraz University of Medical Sciences, Shiraz, Iran , , Amooee، Sedigheh نويسنده Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran , , Aramesh، Shahintaj نويسنده Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. ,
Abstract :
Background: The direct effect of hCG on the human endometrium was studied several times. Objective: The objectives of this study were to evaluate the effectiveness of intrauterine injection of recombinant human chorionic gonadotropin (rhCG) before embryo transfer (ET). Materials and Methods: In this randomized placebo-controlled clinical trial, a total number of 182 infertile patients undergoing their first in vitro fertilization/ intracytoplasmic sperm injection (IVF-ICSI) cycles were randomly assigned to receive 250?g intrauterine rhCG (n=84) or placebo (n=98) before ET. The implantation and pregnancy rates were compared between groups. Results: Patients who received intrauterine rhCG before ET had significantly higher implantation (36.9% vs. 22.4%; p=0.035), clinical pregnancy rates (34.5% vs. 20.4%; p=0.044) and ongoing pregnancy rate (32.1% vs. 18.4%; p=0.032) when compared to those who received placebo. The abortion (2.4% vs. 2.0%; p=0.929) and ectopic pregnancy rates (1.2% vs. 1.0%; p=0.976) were comparable between groups of rhCG and placebo, respectively. Conclusion: Intrauterine injection of 250?g of rhCG before ET significantly improves the implantation and pregnancy rates in IVF/ICSI cycles.
