Author/Authors :
Mashhadi، M.A. نويسنده , , Khazaei، HA نويسنده Associate Professor, Department of Immunology, Zahedan University of Medical Sciences, Zahedan, Iran , , Narouie، B نويسنده Researcher, Clinical Research Development Center, Zahedan University of Medical Sciences, Zahedan, Iran , , Niazi، AA نويسنده Assistant Professor, Department of Pathology, Zahedan University of Medical Sciences, Zahedan, Iran , , Moazzami، K نويسنده Immunology, Asthma and Allergy Research Institute, University of Tehran, Tehran, Iran , , Khademi، R نويسنده Registered Nurse, Zahedan University of Medical Sciences, Zahedan, Iran , , Hejazinia، F نويسنده Registered Nurse, Zahedan University of Medical Sciences, Zahedan, Iran , , Rezaei، N نويسنده Immunology, Asthma and Allergy Research Institute, University of Tehran, Tehran, Iran , , Ghasemi-rad، Mohammad نويسنده Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran ,
Abstract :
Introduction: Hematologic malignancies can be associated with dysregulation of the immune
system. There are some conflicting data regarding serum immunoglobulin levels in patients
with such malignancies.
Material and method: In order to evaluate the humoral immunity of the patients with hematologic
malignancies, 58 patients were enrolled in this study. 24 with acute lymphoblastic
leukemia (ALL), 17 with acute myeloid leukemia (AML), eight with lymphoma, five with
chronic lymphocytic leukemia, and four with multiple myeloma.
Results: There were six cases with decreased serum IgG level (5 AML and 1 ALL). Forty
patients with elevated serum IgG levels (69%).24 with elevated IgA and/or IgM level; 12
patients with elevation in all classes of immunoglobulin (8 ALL, 2 AML, and 2 lymphoma).
Conclusion: Serum immunoglobulin levels can be abnormal in the patients with hematologic
malignancies. Abnormalities of IgG, especially elevated level, seem to be the most frequent
finding encountered in these patients.
