Solubility of cholesterol and its esters in supercritical carbon dioxide with and without cosolvents

The solubilities of cholesterol and its esters—cholesteryl acetate, cholesteryl butyrate and cholesteryl benzoate—in supercritical carbon dioxide were measured using a dynamic flow method. We also examined the effect of a polar cosolvent, namely methanol or acetone, on the solubility of these compounds in supercritical carbon dioxide and found that the solubilities of these compounds are enhanced several fold depending on the pressure of the system. The solubility data were correlated using the Peng–Robinson equation of state (PR EOS) and density-based correlations. Model parameters for the systems studied are obtained through data regression.