Title of article :
Platelet serotonin in combat related posttraumatic stress disorder with psychotic symptoms
Author/Authors :
Pivac، نويسنده , , Nela and Kozaric-Kovacic، نويسنده , , Dragica and Mustapic، نويسنده , , Maja and Dezeljin، نويسنده , , Martina and Borovecki، نويسنده , , Andreja and Grubisic-Ilic، نويسنده , , Mirjana and Muck-Seler، نويسنده , , Dorotea، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Pages :
5
From page :
223
To page :
227
Abstract :
Background -related posttraumatic stress disorder (PTSD) is severe form of PTSD, frequently associated with psychotic symptoms. Platelet serotonin (5-hydroxytryptamine, 5-HT) was used as a peripheral 5-HT marker to identify particular symptoms in PTSD. s et 5-HT was determined fluorimetrically in 67 war veterans with combat related PTSD, 36 combat exposed veterans who did not develop PTSD, 35 veterans with PTSD complicated with psychotic features. PTSD diagnosis of current and chronic PTSD, and clinical symptoms of PTSD and psychoses were assessed according to DSM-IV criteria, using the Clinician Administrated PTSD Scale, and Positive and Negative Syndrome Scale (PANSS). s et 5-HT concentration was significantly higher in veterans with psychotic PTSD than in veterans with non-psychotic PTSD, veterans without PTSD, or in control subjects. Platelet 5-HT was significantly positively correlated with the positive symptoms in PANSS subscale, and with the symptoms of delusions within PANSS positive subscale. tions sults were obtained on peripheral 5-HT marker, i.e. platelet 5-HT concentration. sions the delusions are the core psychotic symptoms occurring in our psychotic PTSD patients, the result of the increased platelet 5-HT concentration, associated with delusions, indicate that platelet 5-HT might be used as a trait marker of psychotic symptoms in PTSD, but not as a state marker for PTSD.
Keywords :
Psychotic symptoms , Platelet serotonin , War veterans , Combat related posttraumatic stress disorder
Journal title :
Journal of Affective Disorders
Serial Year :
2006
Journal title :
Journal of Affective Disorders
Record number :
1431460
Link To Document :
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