Title of article :
Polyelectrolyte-coated liposomes: Stabilization of the interfacial complexes
Author/Authors :
Yaroslavov، نويسنده , , Alexander A. and Rakhnyanskaya، نويسنده , , Anna A. and Yaroslavova، نويسنده , , Ekaterina G. and Efimova، نويسنده , , Anna A. and Menger، نويسنده , , Fredric M.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
10
From page :
43
To page :
52
Abstract :
Anionic liposomes, composed of egg lecithin (EL) or dipalmitoylphosphatidylcholine (DPPC) with 20 mol% of cardiolipin (CL2−), were mixed with cationic polymers, poly(4-vinylpyridine) fully quaternized with ethyl bromide (P2) or poly-l-lysine (PL). Polymer/liposome binding studies were carried out using electrophoretic mobility (EPM), fluorescence, and conductometry as the main analytical tools. Binding was also examined in the presence of added salt and polyacrylic acid (PAA). The following generalizations arose from the experiments: (a) Binding of P2 and PL to small EL/CL2− liposomes (60–80 nm in diameter) is electrostatic in nature and completely reversed by addition of salt or PAA. (b) Binding can be enhanced by hydrophobization of the polymer with cetyl groups. (c) Binding can also be enhanced by changing the phase state of the lipid bilayer from liquid to solid (i.e. going from EL to DPPC) or by increasing the size of the liposomes (i.e. going from 60–80 to 300 nm). By far the most promising systems, from the point of view of constructing polyelectrolyte multilayers on liposome cores without disruption of liposome integrity, involve small, liquid, anionic liposomes coated initially with polycations carrying pendant alkyl groups.
Keywords :
Liposome , Polyanion , Adsorption , Multilayer , Polycation
Journal title :
Advances in Colloid and Interface Science
Serial Year :
2008
Journal title :
Advances in Colloid and Interface Science
Record number :
1432260
Link To Document :
بازگشت