CSF and plasma cytokines at delivery and postpartum mood disturbances

Background activation has been shown to be involved in the pathophysiology of anxiety states and major depression and pregnancy is associated with a characteristic immune activation to sustain the fetus. Despite the possibility of a relation between immune parameters and postpartum mood disturbance, few studies have explored this association. Further, no study to-date has examined CSF. s six Greek parturients were recruited and a detailed medical and obstetric history was recorded. All of them completed the Postpartum Blues Questionnaire (on admission and on days 1–4 postpartum) and the Edinburgh Postnatal Depression Scale (at first and sixth week postpartum). At delivery, a blood sample and a CSF sample while puncturing for epidural analgesia were taken from 33 participants; blood samples only were obtained from the rest of the 23 parturients. TNF-a and IL-6 were quantified with an ELISA assay. s iple regression analysis of psychometric scores depending on cytokine levels revealed that cytokine levels were positively associated with depressive mood during the first four days postpartum (p = 0.035 for CSF IL-6, p = 0.025 for CSF TnF-a, p = 0.023 for serum TnF-a) and also at sixth week postpartum (p = 0.012 for CSF IL-6, p = 0.072 for CSF TnF-a). Pregnancy duration had an adverse association to psychometric scores. sions suggested that immune mechanisms may play a role in the etiopathology of postpartum depressive mood shifts. The role of a “rebound” reaction of the maternal immune system postnatal should be further investigated.