Author/Authors :
Jasenka and Korampally، نويسنده , , Madhuri and Apperson، نويسنده , , Steven J. and Staley، نويسنده , , Clay S. and Castorena، نويسنده , , Jorge A. and Thiruvengadathan، نويسنده , , Rajagopalan and Gangopadhyay، نويسنده , , Keshab and Mohan، نويسنده , , Rajiv R. and Ghosh، نويسنده , , Arkasubhra and Polo-Parada، نويسنده , , Luis and Gangopadhyay، نويسنده , , Shubhra، نويسنده ,
Abstract :
We have developed a novel, operator-friendly, nanothermite reaction actuator which generates transient pressures comprised of a shock wave superimposed on a broad pressure pulse to facilitate intranuclear molecular transport. The actuator demonstrates the delivery of ∼70 kDa FITC-Dextran into chicken cardiomyocytes with cytoplasmic delivery efficiency greater than 90%, maximum intranuclear delivery efficiency of 84%, and cell survival rates exceeding 95% in minimum operating pressure conditions. Tunable nanothermite reactions enable versatile pressure generating characteristics which can extend the technology to a spectrum of biomedical molecular delivery applications.
Keywords :
Nanoenergetics , Shock wave , MEMS , Transfection , Molecular delivery
