Site-binding model as a basis for numerical evaluation of analytical parameters of capacitance-biosensors for formaldehyde and methylamine detection

The development of sensor microsystems, based on the biological recognition of analytes by sensitive molecules, requires numerical tools for the evaluation of sensor analytical characteristics. A digital platform, based on the site-binding model and Mott–Schottky equation, has been developed and used to estimate the responses of semiconductor-based capacitance biosensors for formaldehyde and methylamine determination. It has been demonstrated that the classical site-binding model cannot be applied for the analysis of the sensor behaviour and should be adjusted taking into account the effect of buffer type and its concentration and type as well as membrane composition on the capacitance biosensor response.