Title of article
Evidence for Unusual Stability of ADP-Ribosyl Linkage to Membrane Proteins of a Murine Leukemic Cell Line
Author/Authors
Hanson، نويسنده , , K. and Aboulela، نويسنده , , N. A. Jacobson، نويسنده , , M.K. and Wu، نويسنده , , M.C.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1993
Pages
7
From page
193
To page
199
Abstract
A set of membrane proteins from murine myelomonocytic leukemia cell line WEHI-3BD+ was found to be ADP-ribosylated. Both this ADP-ribosylation reaction and granulocytic differentiation in response to recombinant G-CSF were inhibited approximately 50% by 2 mM benzamide, suggesting a correlation between these two processes. The stability of the ADP-ribosyl linkage was examined under a series of chemical release conditions and was found to resemble none of the known ADP-ribosyl-amino acid linkages. This chemical modification may represent a new class of mono(ADP-ribosyl) modifications of proteins.
Journal title
Archives of Biochemistry and Biophysics
Serial Year
1993
Journal title
Archives of Biochemistry and Biophysics
Record number
1450244
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