Title of article
Electrode potential-controlled DNA damage in the presence of copper ions and their complexes
Author/Authors
Fojta، نويسنده , , Miroslav and Havran، نويسنده , , Lud?k and Kubi??rov?، نويسنده , , Tatiana and Pale?ek، نويسنده , , Emil، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
25
To page
27
Abstract
Supercoiled (sc) DNA immobilized at the surface of a hanging mercury drop electrode was cleaved by reactive oxygen species generated by an electrochemically modulated reaction of copper ions, hydrogen peroxide and/or oxygen. The cleavage was observed in a certain potential region where redox cycling of DNA-bound Cu(II)/Cu(I) took place. In the presence of 1,10-phenanthroline the maximum efficiency of DNA cleavage was shifted to more negative potentials and the effect was enhanced.
Keywords
DNA damage , Mercury electrode , Phenanthroline , copper ions
Journal title
Bioelectrochemistry
Serial Year
2002
Journal title
Bioelectrochemistry
Record number
1450274
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