Title of article
Electrochemical sensing of DNA–adriamycin interactions
Author/Authors
Piedade، نويسنده , , J.A.P. and Fernandes، نويسنده , , I.R. and Oliveira-Brett، نويسنده , , A.M.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
3
From page
81
To page
83
Abstract
Adriamycin, a cancerostatic anthracycline antibiotic, causes considerable death of tumour cells, together with the induction of breaks in DNA single and double strands. The interaction of this compound with DNA was investigated using an electrochemical DNA-biosensor. Adriamycin intercalation in DNA disrupts the double helix and the detection of guanine and 8-oxoguanine could mimic one possible mechanism for the in vivo adriamycin drug action.
Keywords
adriamycin , 8-oxoguanine , Voltammetry , Oxidative damage , DNA-biosensor
Journal title
Bioelectrochemistry
Serial Year
2002
Journal title
Bioelectrochemistry
Record number
1450421
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