The effect of polyamidoamine dendrimers on human erythrocyte membrane acetylcholinesterase activity

Polyamidoamine (PAMAM) dendrimers impact on activity of acetylcholinesterase was studied. It has been shown that dendrimers induce a biphasic effect: depending on their concentrations they increase or decrease enzyme activity. It may be due to two types of interactions: direct—between dendrimers and the enzyme; indirect—via a modification of the physical state of membrane phospholipids affecting the acetylcholinesterase.