Title of article
Kinetic study of the degradation of a potential local anesthetic drug in serum using the DNA-based electrochemical biosensor
Author/Authors
Vanickova، M. نويسنده , , M. and Lehotay، نويسنده , , J. and ?i?m?rik، نويسنده , , J. and Labuda، نويسنده , , J.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
125
To page
127
Abstract
DNA-drug association interaction at the DNA modified screen-printed electrode for 1-methyl-2-piperidinoethylester of 2-hexoxyphenylcarbamic acid was found leading to an accumulation of the drug within the DNA layer. A procedure for the determination of drug in blood serum matrix using the protein precipitation and voltammetric measurement of the electroactive drug with the DNA biosensor was obtained and an effort was done to apply it for an assay of the drug enzymatic degradation in human and rabbit sera at 37 °C.
Keywords
Local anesthetics , serum , DNA electrochemical biosensor , Drug degradation , DP voltammetry
Journal title
Bioelectrochemistry
Serial Year
2005
Journal title
Bioelectrochemistry
Record number
1451378
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