Redox kinetics of adriamycin adsorbed on the surface of graphite and mercury electrodes

Kinetics of the surface redox reactions of adriamycin (doxorubicin hydrochloride) adsorbed on paraffin-impregnated graphite electrode (PIGE) and on mercury electrode is measured by square-wave voltammetry. In 0.9 mol/L KNO3 buffered to pH 4.65, the standard electrode reaction rate constants of the first quinone/hydroquinone redox couple (see Scheme 2) on PIGE and mercury are ks1 = 49 ± 12 s− 1 and ks1 = 147 ± 36 s− 1, respectively. Under the same conditions, the standard rate constant of the second redox couple on the PIGE is smaller than 4 s− 1 and the electron transfer coefficient of the reduction is α2 = 0.35.