Author/Authors :
Qiao، نويسنده , , Jin-ping and Abliz، نويسنده , , Zeper and Chu، نويسنده , , Feng-ming and Hou، نويسنده , , Pei-ling and Zhao، نويسنده , , Li-yan and Xia، نويسنده , , Min and Chang، نويسنده , , Yan and Guo، نويسنده , , Zongru Guo، نويسنده ,
Abstract :
6-Aminobutylphthalide (ABP) is a new drug candidate which is currently being developed for the treatment of cerebral ischemia. The pharmacokinetics and metabolism of ABP were studied using in situ microdialysis sampling in the brains of awake freely-moving rats. Two LC-MS/MS methods were used for the quantitative and qualitative analysis of microdialysate. For comparison and confirmation, brain tissue samples were also analyzed by LC-MS/MS and GC/MS. The results described provide more authentic information in pharmacokinetics and metabolism at the site of action by using the coupling of microdialysis to LC-MS/MS technique than the traditional sampling methods.
