Use of spectral mapping technique for the evaluation of the formation of inclusion complexes between anticancer drugs and cyclodextrin derivatives

Spectral mapping technique has been used for the separation of the strength and selectivity of the relative strength of interaction between 18 commercial anticancer drugs and 7 cyclodextrin derivatives. The potency values of the spectral map was considered as indicators of the capacity of anticancer drugs and cyclodextrins to interact with each other taking all the data into consideration simultaneously. The multidimensional selectivity map was visualized by the two-dimensional nonlinear mapping technique, the iterations was carried out to the point when the difference between the last two iterations was lower than 10−8. It has been established that both the diameter of the cyclodextrin cavity and the number and type of substituents on outer sphere of the cyclodextrin molecules influence the complex forming capacity.