Title of article
Simple and rapid liquid chromatography method for determination of efavirenz in plasma
Author/Authors
Ramachandran، نويسنده , , Geetha and Kumar، نويسنده , , A.K. Hemanth and Swaminathan، نويسنده , , Soumya and Venkatesan، نويسنده , , P. and Kumaraswami، نويسنده , , V. and Greenblatt، نويسنده , , David J.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
5
From page
131
To page
135
Abstract
A simple and rapid high performance liquid chromatographic method for determination of efavirenz in human plasma was developed. The method involved extraction of sample with ethyl acetate and analysis using a reversed-phase C18 column (150 mm) with UV detection. The assay was linear from 0.0625 to 10.0 μg/ml. The method was specific for efavirenz estimation and the drug was stable in plasma up to one month at −20 °C. The average recovery of efavirenz from plasma was 101%. Due to its simplicity, the assay can be used for pharmacokinetic studies and therapeutic drug monitoring of efavirenz.
Keywords
Efavirenz , PLASMA , HPLC
Journal title
Journal of Chromatography B
Serial Year
2006
Journal title
Journal of Chromatography B
Record number
1463106
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