Author/Authors :
Takeuchi، نويسنده , , Tohru and Nakanishi، نويسنده , , Toyofumi and Tabushi، نويسنده , , Yoko and Hata، نويسنده , , Ayu and Shoda، نويسنده , , Takeshi and Kotani، نويسنده , , Takuya and Shimizu، نويسنده , , Akira and Takubo، نويسنده , , Takayuki and Makino، نويسنده , , Shigeki and Hanafusa، نويسنده , , Toshiaki، نويسنده ,
Abstract :
We analyzed the changes in the serum protein profile by infliximab using two-dimensional gel electrophoresis and mass spectrometry. More than 50 gel spots were seen to increase or decrease in correlation with clinical improvements of RA. The spots corresponding to CRP, C3, and Apo J showed reduced staining intensity, while the spots corresponding to Apo A-I, RBP, and transthyretin were enhanced. The protein profile of RA patients treated with infliximab was mostly similar to that of normal healthy controls except for several protein spots. This suggested that infliximab normalized the serum protein profile of RA patients, leading to modification in the serum lipid profile and antioxidant status in RA.
Keywords :
tumor necrosis factor , Matrix assisted laser desorption ionization/time-of-flight mass spectrometry , rheumatoid arthritis , electrophoresis , Infliximab
