Adsorption of histidine-containing dipeptides on copper(II) immobilized chelating resin from saline solution

Adsorption of histidine-containing dipeptides such as carnosine (Car) was investigated using copper(II) immobilized cation exchange resins. Adsorption of Car was enhanced using Cu(II) immobilized resins, on the basis of metal affinity interactions. In particular, iminodiacetic acid chelating resin with immobilized Cu(II) (Cu–IDA) can adsorb Car from saline water. Car was adsorbed on Cu–IDA even in the presence of 1000 mM of NaCl. Adsorption of various amino acids on Cu–IDA was compared under same conditions. Histidine and the histidine-containing dipeptides were selectively adsorbed on Cu–IDA over other amino acids, both in the absence and in the presence of NaCl. Therefore, immobilized metal affinity adsorption is an efficient method for recovering histidine-containing dipeptides from saline water.