Author/Authors :
McNamee، نويسنده , , Pauline M. and Api، نويسنده , , Anne Marie and Basketter، نويسنده , , David A. and Frank Gerberick، نويسنده , , G. and Gilpin، نويسنده , , Deborah A. and Hall، نويسنده , , Barbara M. and Jowsey، نويسنده , , Ian and Robinson، نويسنده , , Michael K.، نويسنده ,
Abstract :
This paper reviews key factors that are critical to the conduct and interpretation of Human Repeat Insult Patch Tests (HRIPTs). A methodology for HRIP testing is described and general guidelines for evaluation of responses indicative of induction and elicitation of skin sensitization and skin irritation are detailed. Understanding and applying these key factors is crucial to the design of such studies and reliability of the resulting data when used in the overall risk assessment process.
Keywords :
skin , Contact allergy , HRIPT , Design , evaluation , Critical factors
