Title of article :
Enantioseparation of selected chiral sulfoxides using polysaccharide-type chiral stationary phases and polar organic, polar aqueous–organic and normal-phase eluents
Author/Authors :
Chankvetadze، نويسنده , , Bezhan and Yamamoto، نويسنده , , Chiyo and Okamoto، نويسنده , , Yoshio، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Abstract :
HPLC enantioseparation of selected chiral sulfoxides was studied using cellulose and amylose phenylcarbamate derivatives as chiral stationary phases (CSPs). The contributions of various functional groups of a chiral analyte as well as the polysaccharide derivatives in the analyte retention and chiral recognition were evaluated. A very high enantioseparation factor exceeding 110 was observed in the enantioseparation of 2-(benzylsulfinyl)benzamide (BSBA) on cellulose tris(3,5-dichlorophenylcarbamate) (CDCPC) CSP by using 2-propanol as a mobile phase. The enantiomer elution order was opposite on cellulose and amylose phenylcarbamates. For the polysaccharide-type CSPs, pure alcohols such as methanol, ethanol and 2-propanol represent a valuable alternative to more common alcohol–hydrocarbon and reversed-phase eluents.
Journal title :
Journal of Chromatography A
Journal title :
Journal of Chromatography A