Characterization of phosphorus-containing gas chromatographic stationary phases by linear solvation energy relationships

Linear solvation energy relationships allow the prediction of a variety of solubility interactions based on a set of descriptors found in the following equation:log SP=c+r1R2+s1π2H+a1 ∑ α2H+b1 ∑ β2H+l1 log L16SP refers to an intrinsic thermodynamic property that can be found experimentally for a series of solutes. Phases containing phosphate, phosphite and phosphine functional groups were studied in this work. Coefficients obtained during this work, as well as those available for previously characterized phases, were correlated with molecular structural descriptors. When effects of non-phosphorus functional groups are estimated and subtracted out, hydrogen bond acceptor capability, a1, shows a positive trend when correlated with percent functional group. Correlation of the dipolarity/polarizability coefficient, s1, with calculated atomic polarizability shows stationary phases group according to like functional groups. A similar correlation with dipole moment gives a trend of increasing dipole as s1 increases. Further quantitative structure–solubility relationship work is planned to better describe the contributions of inner shell and valence electrons to the chemical and physical properties of these compounds.