Simultaneous coaxial thermal lens spectroscopy and retro-reflected beam interference detection for capillary electrophoresis

A novel optical scheme, which accomplished simultaneous coaxial thermal lens spectroscopy and retro-reflected beam interference detection for capillary electrophoresis, has been described. By a special design, an adjustable pump laser waist relative to the probe laser waist was implemented, while some key elements for both detection modes were optimized. In either detection modes, certain preponderance compared with former reports was indicated. With both coaxial thermal lens spectroscopy and retro-reflected beam interference detection, the reported detection scheme combined high sensitivity and universal property for capillary electrophoresis detection.