Title of article :
High-performance liquid chromatographic enantioseparation of β2-amino acids using a long-tethered (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid-based chiral stationary phase
Author/Authors :
Ilisz، نويسنده , , Istvلn and Pataj، نويسنده , , Zoltلn and Berkecz، نويسنده , , Rَbert and Misicka، نويسنده , , Aleksandra and Tymecka، نويسنده , , Dagmara and Fülِp، نويسنده , , Ferenc and Choi، نويسنده , , Hee Jung and Hyun، نويسنده , , Myung Ho and Péter، نويسنده , , Antal، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Pages :
8
From page :
1075
To page :
1082
Abstract :
Reversed-phase high-performance liquid chromatographic methods were developed for the separation of enantiomers of eleven unnatural β2-amino acids on a new chiral stationary phase, using the 11-methylene-unit spacer of aminoundecylsilica gel for the bonding of (+)-(18-crown-6)-2,3,11,12-tetracarboxylic acid as selector. The nature and concentration of the acidic and organic modifiers, the pH, the mobile phase composition, and the structures of the analytes substantially influenced the retention and resolution. Separations were carried out at constant mobile phase compositions in the temperature range 7–40 °C and the changes in enthalpy, Δ(ΔH°), entropy, Δ(ΔS°), and free energy, Δ(ΔG°) were calculated. The elution sequence was determined in some cases: the S enantiomers eluted before the R enantiomers.
Keywords :
?2-Amino acids , Column liquid chromatography , Long-tethered (+)-(18-crown-6)-2 , 3 , 11 , Spacer length effect , 12-tetracarboxylic acid-based chiral stationary phase , Temperature effect
Journal title :
Journal of Chromatography A
Serial Year :
2010
Journal title :
Journal of Chromatography A
Record number :
1512789
Link To Document :
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