Title of article :
1.1 μm superficially porous particles for liquid chromatography. Part I: Synthesis and particle structure characterization
Author/Authors :
Blue، نويسنده , , Laura E. and Jorgenson، نويسنده , , James W.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2011
Pages :
7
From page :
7989
To page :
7995
Abstract :
Superficially porous particles are characterized by a non-porous particle core surrounded by a thin porous layer. Superficially porous particles have been shown to have chromatographic advantages over traditional totally porous particles by reducing the resistance to mass transfer and the eddy diffusion contributions to the theoretical plate height, particularly for biomolecule separations. Currently, 1.7 μm superficially porous particles are commercially available, but a further decrease in the particle diameter and reduction in the porous layer thickness has the potential to further improve the efficiency of the column packing material. In this study, the synthesis of smaller diameter superficially porous particles was investigated. As the particle diameter was decreased, however, synthesis parameters previously reported were rendered unsuitable due to particle agglomeration, non-uniform coating, and porous layer disintegration. Parameters such as colloidal silica size, drying process, and sintering temperature were investigated to improve the structural characteristics of smaller diameter superficially porous particles. Reported is a synthetic route for production of 1.1 μm superficially porous particles having a 0.1 μm porous layer. Based on the revised method, the particles produced have a surface area, pore diameter, and particle size distribution RSD of 52 m2/g, 71 Å, and 2.2%, respectively.
Keywords :
Superficially porous particles , Synthesis , 1  , ?m , pore size , Core–shell
Journal title :
Journal of Chromatography A
Serial Year :
2011
Journal title :
Journal of Chromatography A
Record number :
1514633
Link To Document :
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