Title of article :
Imidazolium-based functional monomers for the imprinting of the anti-inflammatory drug naproxen: Comparison of acrylic and sol–gel approaches
Author/Authors :
Kadhirvel، نويسنده , , Porkodi and Azenha، نويسنده , , Manuel and Shinde، نويسنده , , Sudhirkumar and Schillinger، نويسنده , , Eric and Gomes، نويسنده , , Paula and Sellergren، نويسنده , , Bِrje and Silva، نويسنده , , A. Fernando-Silva، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Pages :
9
From page :
115
To page :
123
Abstract :
Imidazolium-based monomers were, for the first time, employed in a comprehensive investigation of the molecular imprinting process of naproxen in both acrylic and sol–gel tridimensional networks. To this end, molecularly imprinted polymer (MIP) and xerogel (MIX) were both optimized for performance, by testing different porogen, template speciation and component ratios. The developed imprints were characterized for their pore properties (nitrogen adsorption analysis), site heterogeneity, binding properties and other performance parameters such as the imprinting factor, selectivity (HPLC column tests), column efficiency and mass transfer kinetics (frontal analysis study). MIP exhibited mesoporosity (Dp 29 nm), whereas MIX did not, which was reflected in both the lower number of accessible imprinted sites (4.9 μmol/g versus 3.7 μmol/g) and the slower binding/dissociation in MIX. The naproxen/ibuprofen selectivity ratio was estimated as 6.2 for the MIX and 2.5 for the MIP. Given the high importance of capacity and fast mass transfer in typical applications of imprinted materials, and the satisfactory selectivity of MIP, it can be concluded that the acrylic approach was globally the most advantageous. Still, the remarkably high selectivity of MIX and its reasonable capacity demonstrate that future work devoted to further optimization of both formats is worthwhile.
Keywords :
Frontal analysis , molecular imprinting , Cationic monomer , Sol–gel , Methacrylic polymer , Naproxen
Journal title :
Journal of Chromatography A
Serial Year :
2013
Journal title :
Journal of Chromatography A
Record number :
1515181
Link To Document :
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