Title of article :
Study of organic compounds–water interactions by partition in aqueous two-phase systems
Author/Authors :
Madeira، نويسنده , , Pedro P. and Bessa، نويسنده , , Ana and Teixeira، نويسنده , , Miguel A. and ءlvares-Ribeiro، نويسنده , , Luيs and Aires-Barros، نويسنده , , M. Raquel and Rodrigues، نويسنده , , Alيrio E. and Zaslavsky، نويسنده , , Boris Y. Shekunov، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2013
Abstract :
Partition coefficients of fourteen organic compounds were determined in 10 or 20 different polymer/polymer aqueous two-phase systems (ATPS) all at physiological pH (0.15 M NaCl in 0.01 M phosphate buffer, pH 7.4). Solute-specific coefficients characterizing different types of solute–water interactions for the compounds examined were determined by the multiple linear regression analysis. It is shown that (i) the partition behavior for the polar organic compounds is affected not only by dipole–dipole and hydrogen-bond interactions with aqueous environment but, notably, in most cases also by dipole–ion interactions; (ii) it is possible to predict partition behavior for compounds with pre-determined solute-specific coefficients in ATPS with characterized solvent features; and (iii) linear combinations of the solute-specific coefficients for the organic compounds might be useful in the development of quantitative structure–activity relationship (QSAR) analysis to describe their odor detection threshold.
Keywords :
Aqueous two-phase partitioning , Solute-specific coefficients , Ion–dipole interactions , Odor threshold , Organic compounds–water interactions
Journal title :
Journal of Chromatography A
Journal title :
Journal of Chromatography A