Author/Authors :
Clicq، نويسنده , , D and Vervoort، نويسنده , , N and Vounckx، نويسنده , , R and Ottevaere، نويسنده , , H and Buijs، نويسنده , , J and Gooijer، نويسنده , , C and Ariese، نويسنده , , F and Baron، نويسنده , , G.V. and Desmet، نويسنده , , G، نويسنده ,
Abstract :
Utilizing the concept of shear-driven chromatography, we have been able to realize reversed-phase LC separations in flat rectangular nano-channels coated with a C8 monolayer and being as thin as 100 nm. At this scale, the separation kinetics are strongly enhanced, as is witnessed by the extremely short time (<0.1 s) needed to separate a mixture of coumarin dyes. The observed plate numbers are still relatively small, because the experiments were conducted in ultra-short columns (≤1 mm) and under injection band width-limiting conditions.
