Author/Authors :
Pappaert، نويسنده , , K. and Vanderhoeven، نويسنده , , J. and Van Hummelen، نويسنده , , P. and Dutta، نويسنده , , B. and Clicq، نويسنده , , D. and Baron، نويسنده , , G.V. and Desmet، نويسنده , , G.، نويسنده ,
Abstract :
A very simple micro-channel flow system is used to investigate the potential gain in hybridization rate stemming from the induction of a convective flow past the surface of a DNA micro-array. Reporting on a series of preliminary experiments wherein a two-dimensional convective flow is created past the surface of a conventional micro-array slide, the analysis time could be brought down from overnight waiting (16 h) to some 10 to 30 min. The experiments open the road towards the development of novel, convection-driven hybridization systems yielding shorter analysis times, and/or lower detection limits.
