Improved model of multicomponent adsorption in reversed-phase liquid chromatography

This work presents a modification to the real adsorbed solution model using a Flory–Huggins type of expression that was reported previously. This modification consists in replacing the Flory–Huggins activity coefficient by the spreading pressure dependent approach. This new model takes into account explicitly the adsorbate–adsorbate interactions taking place in the adsorbed phase. It provides an excellent prediction of the competitive, ternary adsorption equilibrium of benzyl alcohol, 2-phenylethanol and 2-methyl benzyl alcohol observed in a reversed-phase liquid chromatographic system using information merely derived from the single-component adsorption experimental data.