Solute–solvent interactions in micellar liquid chromatography: Characterization of hybrid micellar systems of sodium dodecyl sulfate–pentanol

The solvation parameter model has been applied to the characterization of hybrid micellar chromatographic systems with mixtures of sodium dodecyl sulfate (SDS) and pentanol as mobile phases. Retention factors for 22 compounds in two groups, phenethylamines and antihistamines, were used for the characterization of the systems after the calculation of their Abraham descriptors. Three equations were developed as multiple linear regressions using Abraham descriptors and properties, such as log Poct and polar surface area to correlate the retention factors. A group of 30 data points was used as an independent test set to assess the predictive capability of the equations. Micellar chromatographic systems were compared against other separation systems using principal components analysis. Conventional RPLC chromatography using mobile phases with high amounts of organic solvents are close to the micellar mobile phases that only use small amounts of alcohol.