Is There a Link Between Changes in the Vertebral “hoxcode” and the Shape of Vertebrae? A Quantitative Study of Shape Change in the Cervical Vertebral Column of Mice

Homeobox (hox) genes are of considerable importance in the formation of the body axis of invertebrates and vertebrates. The postulation of ahox-code (i.e. the simultaneous activity of a certain subset ofhoxgenes) for structures at different metameric levels and which differ from each other in shape suggests a relationship betweenhox-code and shape, which is reinforced by the possibility of homeotic transformation when thehox-code is changed experimentally. This paper considers the possible nature of such a relationship between thehoxgenes governing vertebral formation in the upper part of the mouse vertebral column and the shape of the adult vertebrae formed in this region.