Analysis of Genomic Patchiness ofHaemophilus influenzaeandSaccharomyces cerevisiaeChromosomes

We have analysed some aspects of the primary structure of the chromosome of the prokaryoteHaemophilus influenzaeand of the eukaryoteSaccharomyces cerevisiaethat share the same G+C content. In particular, we have investigated genomic patchiness over the gene size level (10 Kb) and that patchiness due to long homogeneous tracts. Long polypurine and polypyimidine tracts that are largely over-represented inS. cerevisiaechromosomes and under-represented inH. influenzae, are responsible for a large fraction of long correlation signals. Generating mechanisms of long homogeneous tracts are DNA replication slippage and duplication events that appear to be linked processes driving chromosome primary structure evolution.