Title of article :
Are Only Repeated Triplets Guilty?
Author/Authors :
De Fonzo، نويسنده , , Valeria and Bersani، نويسنده , , Enrico and Aluffi-Pentini، نويسنده , , Filippo and Castrignanٍ، نويسنده , , Tiziana and Parisi، نويسنده , , Valerio، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Pages :
18
From page :
125
To page :
142
Abstract :
It is well known that in some places of the human genome one finds a variable number of tandem repeats of trinucleotides; it is now commonly acknowledged that in many cases an excessive expansion of such a number is the cause of nervous system diseases. Moreover there exist cases of genetic disorders linked with loci where a variable number of tandem repeats of sequences longer than three bases has been found. The abnormal number of these repeats in few cases has been associated with the onset of the disease. Considering the above facts, we have performed an extensive study of published sequences of genes connected with various diseases. We have examined, inside or near those genes, all possible tandem repeats. alysis has led to the detection of a large number of repeats of both triplets and longer sequences, many of which, as far as we know, had not been pointed out before. sults of our analysis lead us to put forward the hypothesis that in more cases than those till now established, a variable number of tandem repeats of generic sequences, not only of triplets, could be associated with disease onset. y we suggest to allocate experimental researches for all the possible tandem repeats and their possible correlation with the neurodegenerative disorders and with other kinds of syndromes.
Journal title :
Journal of Theoretical Biology
Serial Year :
1998
Journal title :
Journal of Theoretical Biology
Record number :
1533563
Link To Document :
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