Nonlinear features in protein circuitry

The noise involved in protein circuit can result in fluctuations in protein concentrations. Then we have explored the effect of such noise on the feedback loop between p53 and its repressor Mdm2, the negative feedback dynamics and oscillatory activities are presented. Recent experimental results show that under certain conditions, the activity of the average protein level of p53 behaves with dampened oscillation in response to DNA damage, and it has non-decaying oscillatory behavior in individual cells, and we show that the dampening is induced by intrinsic noise, namely the uncertainty associated with chemical kinetics in dealing with when and in what order reactions take place in the p53 system. Furthermore, the experimental results are reproduced in this paper.