Title of article :
Predicting the fate of microRNA target genes based on sequence features
Author/Authors :
Pei، نويسنده , , Yunfei and Wang، نويسنده , , Xi and Zhang، نويسنده , , Xuegong، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
6
From page :
17
To page :
22
Abstract :
MicroRNAs (miRNAs) are important post-transcriptional regulators that repress gene expression by binding to the 3′UTRs of their target mRNAs. There are two main outcomes for the transcripts targeted by miRNAs: mRNA degradation and translational repression. It is still unclear what factors determine whether a target transcript is degraded or translationally repressed. In this study, we collected two classes of genes that are targeted by miR-1, miR-155, miR-16, miR-30a, and let-7b and built new computational models with machine-learning methods to predict the fates of target genes based on sequence features. The prediction results indicate that the sequence context of the miRNA binding site at the 3′UTR of a target gene plays an important role in determining how an miRNA regulates the expression of its target. Further analysis shows that four out of the five studied miRNAs probably share similar regulatory mechanisms on their target genes.
Keywords :
Target mRNA , Degradation , MicroRNA , repression
Journal title :
Journal of Theoretical Biology
Serial Year :
2009
Journal title :
Journal of Theoretical Biology
Record number :
1539882
Link To Document :
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