The implications of gene heterozygosity for protein folding and protein turnover

The offspring of closely related parents often suffer from inbreeding depression, sometimes resulting in a slower growth rate for inbred offspring relative to non-inbred offspring. Previous research has shown that some of the slower growth rate of inbred organisms can be attributed to the inbred organisms’ increased levels of protein turnover. This paper attempts to show that the higher levels of protein turnover among inbred organisms can be attributed to accumulations of misfolded and aggregated proteins that require degradation by the inbred organisms’ protein quality control systems. The accumulation of misfolded and aggregated proteins within inbred organisms are the result of more negative free energies of folding for proteins encoded at homozygous gene loci and higher concentrations of potentially aggregating non-native protein species within the cell. The theory presented here makes several quantitative predictions that suggest a connection between protein misfolding/aggregation and polyploidy that can be tested by future research.